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Bone Lab Dresden

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Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.

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Research Blog & News

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Wir waren bei der Rewe Team Challenge dabei – dem Knochen zuliebe!

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Dresden, 31.05.2019

Denn Laufen stärkt die Knochen

Knochen können nur stark werden und stark bleiben, wenn sie regelmäßig kräftig belastet werden. Schon dreimal 15 Laufminuten pro Woche sorgen dafür, dass das Risiko, Osteoporose zu bekommen, um bis zu 40 Prozent sinkt. Mit der Belastung steigt die Knochendichte, dies schützt vor Frakturen und Osteoporose. Knochenverlust und dessen Behandlung ist nur eines der vielen Themen, mit denen sich das Bone Lab beschäftigt.

Ulrike Baschant läuft seit vielen Jahren und trainiert regelmäßig. „Laufen gehört für mich einfach zu einem erfüllten gesunden Leben. Nach jedem Lauf fühle ich mich mental und körperlich lebendig und frisch.” Für Andy Göbel ist „Laufen eine ideale Sportart, frische Luft zu tanken und mental abzuschalten – man fühlt einfach, wie es den ganzen Körper aktiviert und Stress abbaut. Das kann nur gesund sein.” „Im Dynamo-Stadion mit tausenden anderen Sportlern ins Ziel einzulaufen, ist ein unvergleichliches Gefühl“, so Anja Strehle. Tomas Helbing, Koordinator am UniversitätsCentrum für Gesundes Altern, bereitet sich damit auf einen im Juli geplanten 24h-100km Mammut-Marsch bei München vor.

Was ist wohl für unsere vier Laufsportler das nächste Ziel? Hauptsache bewegen! Gelenke und der Stützapparat werden es danken.

Elena Tsourdi is awarded the Clinical Fellowship 2019

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Dresden, 28.05.2019

Elena Tsourdi is ECTS Clinical Fellowship Awardee 2019 having been granted 10.000€ for clinical research in the field of bone disease. With the project ‘The effect of antiresorptive and osteoanabolic drugs on the expression of bone-specific microRNAs in women with postmenopausal osteoporosis’ she and her collaborators plan to test whether bone-specific miRNAs are differently regulated by osteoporosis therapeutics.

MicroRNAs (miRNAs) regulate various cell functions by inhibiting target gene expression, and bone-specific miRNAs can be potential diagnostic tools in postmenopausal osteoporosis. The main goal of this project is to identify miRNAs which are involved in the pathogenesis of postmenopausal bone loss and to examine their regulation by antiresorptive and osteoanabolic drugs. We will analyse sera from an established cohort of postmenopausal women which were either treatment-naïve, or had received 1-2 yearly i.v. infusions of 5 mg zoledronic acid (ZOL), or had completed 24 months of daily s.c. injections of 20 µg teriparatide (TPTD). The central hypothesis is that bone-specific miRNAs are differently regulated by osteoporosis therapeutics. In order to test the hypothesis we will analyse miRNA-profile regulation by osteoporosis therapeutics and seek to identify correlations between miRNAs and changes in bone mineral density, serum concentrations of established bone turnover markers and myostatin in treatment-naïve and pretreated postmenopausal women. This characterization of the miRNA-profile will lead to a better understanding of the pathogenesis of postmenopausal osteoporosis and may thus contribute to the development of innovative therapeutic approaches.

Franziska Lademann wins this year’s Von Recklinghausen Prize

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Dresden, 21.03.2019

The German Society for Endocrinology (DGE) supports and awards outstanding achievements in basic and clinical research . The Von Recklinghausen Award honors outstanding original scientific work in the field of calcium regulating hormones and bone metabolism. Franziska Lademann won this year’s award with her work on “Lack of the thyroid hormone transporter MCT8 in osteoblast and osteoclast progenitors increases trabecular bone in male mice”! Thyroid hormones are important for maintaining a healthy bone. Their transport into target cells is mediated by transporter proteins, such as the monocarboxylate transporter 8 (Mct8). Targeted knockdown of Mct8 gene expression in bone-building osteoblasts as well as bone-degrading osteoclasts in male mice led to an increase in trabecular bone mass. Both murine models suggest that MCT8 plays an important role in bone metabolism. Further experiments are needed to reveal the exact cellular mechanisms and processes behind it. The award ceremony took place at the annual conference of the German Society of Endocrinology on 21.03.2019 in Göttingen. Congratulations!

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Contact

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Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
eMail: info@bone-lab.de
Fetscherstraße 74 · 01307 Dresden · Germany