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Bone Lab Dresden

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Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.

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Research Blog & News

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Auszeichnung für Dresdner Knochenforscher

Bei der Jahrestagung der Deutschen Gesellschaft für Endokrinologie (DGE) werden herausragende wissenschaftliche Arbeiten auf dem Gebiet der Osteologie mit dem von Recklinghausen Preis ausgezeichnet. In diesem Jahr wurde diese Ehre einem Forscherteam des Bone Lab Dresden zuteil.

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Dresden, 09.03.2021

Dr. med. univ. Nikolai Jaschke gelang unter der Supervision von PD Dr. Tilman Rachner und Dr. Andy Göbel der Nachweis einer neuen Funktion des Proteins Dickkopf-1 (DKK1). „Dickkopf-1 ist primär für seine Rolle in der Regulation des Knochenstoffwechsels bekannt. In unseren Untersuchungen konnten wir nun jedoch anhand klinischer Daten, Zell- und Tierversuchen eine wichtige Rolle des Proteins bei Entzündungsreaktionen identifizieren. Diese Ergebnisse könnten eine plausible Erklärung für die Assoziation hoher DKK-1 Produktion durch Malignomen und der Entwicklung von Knochenmetastasen darstellen, sowie eine therapeutische Relevanz für andere, weitverbreitet Entzündungs-assoziierte Erkrankungen haben“ berichtet Nikolai Jaschke.

„Wir hoffen, dass unsere Studie wichtige Erkenntnisse zum pharmakologischen Potential DKK-1-basierter Therapien liefern kann“, so Tilman Rachner.

Nikolai Jaschke hat an der medizinischen Universität Innsbruck 2018 sein Medizinstudium abgeschlossen und absolviert derzeit gefördert von der Studienstiftung des Deutschen Volkes und dem Mildred-Scheel-Nachwuchszentrum Dresden sein PhD-Studium in der Arbeitsgruppe Rachner/Göbel im Bone Lab von Prof. Hofbauer und Prof. Rauner an der TU Dresden. Anfang 2022 wird Herr Jaschke voraussichtlich nach Abschluss seines PhD zurück in den klinischen Alltag wechseln.

FOP Germany supports the Bone Lab Dresden

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Dresden, 03.11.2020

Last week, we received the wonderful news that the FOP Association in Germany (www.fop-ev.de), a patient organization, will support research in the Bone Lab Dresden that is connected to heterotopic ossification and FOP. Receiving such a generous gift from FOP eV is a tremendous honor and highly motivating! We are delighted to have the support from such an active patient group!

FOP is an ultra-rare disease that is characterized by excessive heterotopic ossification that progressively limits movement. All patients with FOP have a characteristic malformation of the great toe, thus, rendering this malformation a diagnostic criterion for the disease. FOP results from mutations in the ACVR1 gene, which encodes for the BMP type I receptor ALK2. These mutations lead to hyper-responsiveness of this receptor to various ligands of the TGFb/BMP superfamily. The Bone Lab has recently discovered the potential of Tfr2-ECD to limit heterotopic ossification in mouse models by scavenging these ligands. Future research, also supported by the Eva Luise and Horst Köhler Foundation for Rare Diseases, will investigate if this treatment also has potential to reduce ossifications in FOP.

The Bone Lab is dedicated not only to contribute to identifying novel disease mechanisms and/or therapeutic options for FOP, but also to raise awareness for this rare disease. As such, we recently participated in the ECTS Charity Run (https://www.ects2020.org/mediaroom/ects-ects-academy-charity-event-run-for-fop/), which raised funds for FOP France, and won the category for “Best Map”. We hope that with leaving this Foot print, people will be made aware of FOP.

Tracing Iron

 Newly funded Research Unit FerrOs studies effects of iron metabolism on bone and liver health. Professor Martina Rauner and associates receive 4.5 million Euros for DFG Research Group.

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Dresden, 16.10.2020

The trace element iron is essential for life. The liver is a central organ for iron homeostasis and maintains systemic iron levels in a narrow range that is optimal for human health. Iron deficiency is commonly the result of inappropriate uptake as in vegetarians or after chronic blood loss. The resulting iron-deficiency anemia is a common disease of the elderly. However, iron overload due to hematologic or genetic disorders is also detrimental for health and may damage a variety of organs, including the liver, the heart, the pancreas, and the testes. Also, bone is susceptible to iron alterations, since both iron deficiency and overload impair bone strength and promote fragility fractures.

The Deutsche Forschungsgemeinschaft is now funding The Research Unit „Role of iron metabolism in the osteohepatic axis“ (FerrOs) with 4.5 million € over four years. Professor Martina Rauner from the Bone Lab Dresden & the Center for Healthy Aging (Department of Medicine III) of the Universitätsklinikum Dresden coordinates this interdisciplinary consortium. The researchers try to decipher the fine-tuning of iron regulation between the liver and bone and clarify the role of hepcidin, ferroportin, and BMP signaling in this communication.

To this end, TU Dresden scientists cooperate with groups from Heidelberg, Münster, Ulm and Zürich in nine projects, five of which involve Dresden-based PIs, including Martina Rauner, Ulrike Baschant and Lorenz Hofbauer. With this program, the FerrOs group aims to obtain new insights into mechanisms of iron-related disorders and to develop novel dual therapies that concurrently target bone and liver diseases in patients in the future.

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Contact

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Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
eMail: info@bone-lab.de
Fetscherstraße 74 · 01307 Dresden · Germany