Bone Lab Dresden


Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.

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Research Blog & News

Ingo Grafe

Baylor College Scientist Presents Update on Osteogenesis Imperfecta


Dresden, 16.11.2018

Dr. med. Ingo Grafe, a German clinician scientist currently working with the group of Brendan Lee at the Department of Molecular and Human Genetics at Baylor College of Medicine in Houston, Texas, will give a talk on osteogenesis imperfecta on 3rd December at 3 pm in the lecture hall at house 19 (DINZ) in a joint symposium of the Center for Healthy Aging (UCGA) and the Center for Rare Diseases (UCSE) at UKD. He will give new insights into the therapy of the disease and will present novel therapeutic targets for its treatment both in adults and children. The research group of Prof. Brendan Lee is one of the most prestigious and productive genetic bone groups in the US and Dr. Grafe is looking forward to sharing his expertise with both clinicians and scientists here in Dresden.

All physicians, scientists, and students are welcome.

For more information, view the program.

Brendan Lee Lab: https://www.bcm.edu/research/labs/brendan-lee

Strong bones and less fat

Strong bones and less fat – Scientists from Dresden and Leipzig identify novel molecular switch of bone and energy metabolism


Dresden, 09.11.2018

The formation of bone and fat is very much interdependent as both tissues originate from the same type of progenitor cells: mesenchymal stem cells. These either evolve into osteoblast, cells that build up bone mass, or into adipocytes, fat cells, respectively. Factors supporting the formation of fat tissue inhibit bone regeneration at the same time and thereby negatively impact bone quality.

A team of scientists from the Universities of Dresden, Leipzig and Ulm has now identified a novel protein controlling this interaction in a study recently published in Science Translational Medicine. CD90/Thy-1, as the protein is named, enhances bone regeneration, while concurrently inhibiting the accumulation of fat tissue. Mice lacking this protein have brittle bone and grow fatter. Furthermore, the scientists showed that both patients with osteoporosis and patients who are overweight exhibit lower serum levels of CD90/Thy-1 than healthy patients. Further investigations will likely reveal, whether this factor can be applied to improve bone quality in patients with overweight in future, or act as a marker for early diagnosis of bone loss.

Further information: Press release

Original publication in Science Translation Medicine: “Thy-1 (CD90) promotes bone formation and protects against obesity“, Doi:10.1126/scitranslmed.aao680.


Bone health is a crucial factor to assure quality of life


Dresden, 01.11.2018

A novel review of Tilman Rachner describes how adjuvant endocrine therapies of breast and prostate cancer impair bone health to reduce risk of fracture. Preservation of bone health still remains a long-term clinical challenge in patients with breast and prostate cancer. Dr. Rachner emphasizes: “Each patient receiving endocrine therapy should be stringently assessed for their individual fracture risk when therapy is initiated, and this risk should be reassessed in adequate intervals or whenever major changes to disease status or treatment occur.”

Bone health during endocrine therapy for cancer, Tilman D Rachner, Robert Coleman, Peyman Hadji, Lorenz C Hofbauer, 2018

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Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
eMail: info@bone-lab.de
Fetscherstraße 74 · 01307 Dresden · Germany