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Bone Lab Dresden

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Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.

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Research Blog & News

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Congratulations to Maria Ledesma Colunga and Giulia Furesi on their great achievements at the ECTS Digital Congress 2021!

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Dresden, 17.05.2021

Giulia Furesi and Maria Ledesma Colunga, both young scientists from the Dresden Bone Lab, received the opportunity to present their research on the ECTS Digital Congress 2021 in form of an oral presentation.

Giulia Furesi presented her PhD thesis work in the osteooncology field as an oral presentation in the basic/translational session: Cancer, Regeneration and Stem Cells with the title: “Extracellular vesicles from metastatic prostate cancer modulate osteoblastic functions”. Her abstract has been selected for the ECTS Travel Award.

Maria Ledesma Colunga, a Postdoc interested in osteohematology and osteimmunology, presented her latest results in the session Progress in Translational Research as a plenary oral presentation, entitled “Deletion of Transferrin Receptor 2 (Tfr2) aggravates inflammation and bone erosion by promoting macrophage activation in inflammatory arthritis”. Moreover, Maria obtained the New Investigator Award for her Abstract.

We are proud of having such highly motivated and ambitious young scientists in our Bone Lab!

Auszeichnung für Dresdner Knochenforscher

Bei der Jahrestagung der Deutschen Gesellschaft für Endokrinologie (DGE) werden herausragende wissenschaftliche Arbeiten auf dem Gebiet der Osteologie mit dem von Recklinghausen Preis ausgezeichnet. In diesem Jahr wurde diese Ehre einem Forscherteam des Bone Lab Dresden zuteil.

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Dresden, 09.03.2021

Dr. med. univ. Nikolai Jaschke gelang unter der Supervision von PD Dr. Tilman Rachner und Dr. Andy Göbel der Nachweis einer neuen Funktion des Proteins Dickkopf-1 (DKK1). „Dickkopf-1 ist primär für seine Rolle in der Regulation des Knochenstoffwechsels bekannt. In unseren Untersuchungen konnten wir nun jedoch anhand klinischer Daten, Zell- und Tierversuchen eine wichtige Rolle des Proteins bei Entzündungsreaktionen identifizieren. Diese Ergebnisse könnten eine plausible Erklärung für die Assoziation hoher DKK-1 Produktion durch Malignomen und der Entwicklung von Knochenmetastasen darstellen, sowie eine therapeutische Relevanz für andere, weitverbreitet Entzündungs-assoziierte Erkrankungen haben“ berichtet Nikolai Jaschke.

„Wir hoffen, dass unsere Studie wichtige Erkenntnisse zum pharmakologischen Potential DKK-1-basierter Therapien liefern kann“, so Tilman Rachner.

Nikolai Jaschke hat an der medizinischen Universität Innsbruck 2018 sein Medizinstudium abgeschlossen und absolviert derzeit gefördert von der Studienstiftung des Deutschen Volkes und dem Mildred-Scheel-Nachwuchszentrum Dresden sein PhD-Studium in der Arbeitsgruppe Rachner/Göbel im Bone Lab von Prof. Hofbauer und Prof. Rauner an der TU Dresden. Anfang 2022 wird Herr Jaschke voraussichtlich nach Abschluss seines PhD zurück in den klinischen Alltag wechseln.

FOP Germany supports the Bone Lab Dresden

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Dresden, 03.11.2020

Last week, we received the wonderful news that the FOP Association in Germany (www.fop-ev.de), a patient organization, will support research in the Bone Lab Dresden that is connected to heterotopic ossification and FOP. Receiving such a generous gift from FOP eV is a tremendous honor and highly motivating! We are delighted to have the support from such an active patient group!

FOP is an ultra-rare disease that is characterized by excessive heterotopic ossification that progressively limits movement. All patients with FOP have a characteristic malformation of the great toe, thus, rendering this malformation a diagnostic criterion for the disease. FOP results from mutations in the ACVR1 gene, which encodes for the BMP type I receptor ALK2. These mutations lead to hyper-responsiveness of this receptor to various ligands of the TGFb/BMP superfamily. The Bone Lab has recently discovered the potential of Tfr2-ECD to limit heterotopic ossification in mouse models by scavenging these ligands. Future research, also supported by the Eva Luise and Horst Köhler Foundation for Rare Diseases, will investigate if this treatment also has potential to reduce ossifications in FOP.

The Bone Lab is dedicated not only to contribute to identifying novel disease mechanisms and/or therapeutic options for FOP, but also to raise awareness for this rare disease. As such, we recently participated in the ECTS Charity Run (https://www.ects2020.org/mediaroom/ects-ects-academy-charity-event-run-for-fop/), which raised funds for FOP France, and won the category for “Best Map”. We hope that with leaving this Foot print, people will be made aware of FOP.

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Contact

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Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
eMail: info@bone-lab.de
Fetscherstraße 74 · 01307 Dresden · Germany