Bone Lab Dresden
Maintaining lifelong bone health remains a challenge. Therefore, our team works on several research projects linking bone research with diabetes, hematology, immunology, endocrinology, oncology, and materials science. Through our research, we expect to translate bone discoveries into more effective therapies for patients.
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Research Blog & News
Elena Tsourdi received a grant to investigate the impact of hypethyroidism on osteocytes
PD Dr. med. habil. Elena Tsourdi has been awarded a grant from the Fritz Thyssen foundation to investigate the impact of hyperthyroidism on osteocytes. During the last 7 years she has assessed how thyroid hormones interact with bone cells especially through the regulation of the Wnt signaling pathway.
Now, she will expand her research on osteocytes, testing the hypothesis of whether hyperthyroidism can induce mobilization of bone mineral by the osteocyte and thus lead to bone loss. Her aim is to better understand these pathophysiological mechanisms which help to develop more individualized approaches to prevent and treat thyroid hormone-associated bone disease.
The Fritz Thyssen Foundation was the first large private individual foundation established in the Federal Republic of Germany after the Second World War. It promotes several fields of scientific research, devoting special attention to medical research.
Mit Sport Brücken schlagen – Eine Chirurgin, ein Knochenforscher und ein Maschinenbauingenieur radeln für die Hochschulmedizin Dresden
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New funding to investigate innovative treatment approach for Osteogenesis Imperfecta
The Bone Lab Dresden received another funding from the DFG to investigate a new treatment approach for Osteogenesis Imperfecta (OI), also known as “brittle bone disease”, a genetic bone disorder that is characterized by low bone mass, reduced bone strength, and fractures. Project leader, Dr. Ingo Grafe, and his research team will analyse to what extent TGF-β-inhibition can improve the treatment response to intermittent PTH treatment in OI. Dr. Grafe joined the Bone Lab and the Division of Endocrinology, Diabetes, and Bone Diseases at the Universitätsklinikum Dresden in the end of 2019 as a Clinician Scientist. He is an expert in bone disorders, mouse models of bone diseases, and signaling pathways that control bone homeostasis.
Based on preliminary findings, Dr. Grafe believes that the results of his project will provide important new insights of the molecular and cellular mechanisms that contribute to the bone fragility in Osteogenesis Imperfecta, and that these findings may also translate into a novel treatment concept that is based on the distinct pathophysiology of OI. Furthermore, the mechanistic insights learned within this three-year project could also translate to other common bone diseases, such as osteoporosis, and might pave the way for better bone treatment options.
Bone Lab Dresden
Medizinische Klinik und Poliklinik III
Universitätsklinikum Carl Gustav Carus Dresden
Phone: +49 (0)351 458-3173
Fetscherstraße 74 · 01307 Dresden · Germany